Chosen candidates will study the evolution of signaling networks using genomics, proteomics and bioinformatics tools. Projects will aim at understanding the evolution of protein-protein interactions among signaling molecules and the role of gene duplication in shaping these networks. The budding yeast Saccharomyces cerevisiae and its
relatives will be used as models but other relevant species could also be used. We have tools to study protein-protein interactions on a genome-wide scale.
Our research is funded by the Canadian Institutes of Health Research (CIHR) and the Fonds de la Recherche en Sante du Quebec (FRSQ). Research will be conducted at the Laval University Institut de Biologie Intégrative et des Systèmes (IBIS), in Québec City, Canada.
IBIS hosts more than 30 researchers working in genetics, genomics and proteomics as well as organismic biology. Laval University is one of the oldest universities in North America and is a major research institution in Canada. Quebec city is a magnificent and vibrant city.
Competitive stipend + bonus for students who can obtain external fellowships.
Starting date: September 2009 or January 2010
Requirements: The ideal candidate is highly motivated, has experience or training in molecular biology, biochemistry or microbiology, is interested in evolution and has basic skills in bioinformatics.
Pertinent references:
How perfect can protein interactomes be? Science Signaling 2009.
Weak functional constraints on phosphoproteomes. Trends in Genetics 2009.
Systems biology spins off a new model for the study of canalization. Trends in Ecology and Evolution 2009.
An in vivo map of the yeast protein interactome. Science 2008.
Genetic properties influencing the evolvability of gene expression.
Science 2007.
Systems-level analysis and evolution of the phototransduction network
in Drosophila. PNAS 2007.
Interested candidates should send an application with a complete CV,
academic transcripts and a short statement of interest by email and
have three letters of references sent to:
clandry-at-post.harvard.edu
Letters of recommendation from these references should be sent separately.
Informal inquiries are welcome,
Christian Landry, PhD
Département de Biochimie
Faculté de Médecine
Université de Montreal
C.P. 6128, Succ. Centre-Ville
Montreal, Quebec, Canada H3C 3J7
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